منابع مشابه
Viral Carcinogenesis: Factors Inducing DNA Damage and Virus Integration
Viruses are the causative agents of 10%-15% of human cancers worldwide. The most common outcome for virus-induced reprogramming is genomic instability, including accumulation of mutations, aberrations and DNA damage. Although each virus has its own specific mechanism for promoting carcinogenesis, the majority of DNA oncogenic viruses encode oncogenes that transform infected cells, frequently by...
متن کاملA large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration.
We have probed the nucleoprotein organization of Moloney murine leukemia virus (MLV) pre-integration complexes using a novel footprinting technique that utilizes a simplified in vitro phage Mu transposition system. We find that several hundred base pairs at each end of the viral DNA are organized in a large nucleoprotein complex, which we call the intasome. This structure is not formed when pre...
متن کاملReplication, integration, and packaging of plasmid DNA following cotransfection with baculovirus viral DNA.
Infection-dependent replication assays have been used to identify numerous putative origins of baculovirus replication. However, plasmid DNA, when cotransfected into insect cells with Autographa californica multinucleocapsid nucleopolyhedrovirus (AcMNPV) DNA, replicates independently of any viral sequence in cis (11). Cotransfection of transfer plasmids and baculovirus DNA is a common procedure...
متن کاملInvestigation of DNA Integration into Reproductive Organs Following Intramuscular Injection of DNA in Mice
Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic, and tumor antigens has been reported to trigger protective immunity. The use of plasmid DNA vaccinations against many diseases has produced promising results in animal and human clinical trials; however, safety concerns about the use of DNA vaccines exist, such as the possibility of integration into the host gen...
متن کاملOncogenes at viral integration sites.
Most retroviruses are innocuous to the cells they infect and do not encode transforming genes, yet many are implicated in naturally occurring cancers that arise at high frequency in virus-infected animals. It is now clear that the oncogenic properties of these viruses can be attributed to the stochastic activation of cellular oncogenes by the insertion of proviral DNA. Specific cancers ensue fr...
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ژورنال
عنوان ژورنال: Nature
سال: 1971
ISSN: 0028-0836,1476-4687
DOI: 10.1038/234368a0